The heroine spends most of her time in New Orleans and surrounding areas in the state of Louisiana. The story takes place in the years 1765-1780, a crucial period for North America. In contrast to previous protagonists of the cycle, Aveline is in no way affiliated with Desmond Miles. The player assumes the role of Aveline de Gandpré, dark-skinned resident of the New Orleans, who decides to fight for freedom and justice in the ranks of the Assassins. The story of Assassin's Creed: Liberation HD coincides with what is offered on the original version for PS Vita. The version for PCs and stationary consoles, in addition to improved graphics, includes a number of changes in gameplay. The original production was a spin-off of an extremely popular series of action games by Ubisoft, telling the story of the eternal conflict between the Order of the Assassins and the Knights Templar.

Assassin's Creed: Liberation HD is a re-release of Assassin's Creed III: Liberation, originally designed for the PlayStation Vita portable console.

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